The Blonde Leading the Blonde is the second part of the 10th aired and 9th produced episode in season 4 of Dexter's Laboratory, which first aired on September 19, 2003. In this episode, Dexter refuses to admit that blondes have more fun, so Dee Dee secretly dyes his hair blond to prove it to him.
At the beginning of the episode Dexter is reading a book titled "I Know Why The Negative Isotope Sings" it was later changed in mid-episode to "I Know Why The Caged Isotope Sings" after Dee Dee bleaches Dexter's hair. This could be a last minute title adjustment.
As Dexter and Dee Dee are dancing, an action figure of Samurai Jack can be seen on his bookshelf.
This episode was featured on the UK compilation DVD "Toon Foolery-Fool About Laughing".
The song Dexter and Dee Dee dance at the end of the episode has a similar melody to the one sung by the Boy Band Virus, at Head Band episode.
The book, "I Know Why the Caged Isotope Sings", is a reference to Maya Angelou's autobiography I Know Why the Caged Bird Sings.
The episode references to the common myth that people with blonde hair tend to have more fun.
Dexter pulling his shirt down while stepping over a vent is a reference to the 1955 film The Seven Year Itch.
Dexter gives a high-five to the president which resembles George W. Bush, the 43rd president at the time.
Although this episode aired on September 19, 2003, it was actually made in 2002 according to the credits. It was also the final episode produced in 2002 along with its sisterepisodes.
This episode completed production by December 2002.