Mandark's house is a small yellow adobe with a brown roof and two floors. The inside is completely yellow as well.
In seasons 3 and 4, the house is white with a green roof, and its interior is wooden with no wallpaper or painting, with candles and colorful peace sign posters all around.
Behind the house is Mandark's Laboratory which is exceedingly larger than the house and can be seen from afar.
- Mandark's Laboratory
- Mandark's room
- Living room
- Downstairs hall
- Upstairs hall
- Dexter's Rival (only outside seen)
- Mandarker (only outside seen)
- Rushmore Rumble (only outside seen)
- Quackor the Fowl
- Let's Save the World You Jerk!
- Momdark (only outside seen)
- A Boy Named Sue
- Mountain Mandark
- Babe Sitter
- 2 Geniuses 2 Gether 4 Ever
- Garage Sale
- A Mandark Cartoon
- Used Ink (only outside oeen)
- The interior of the house was never fully explored until seasons 3 and 4, with only Mandark's bathroom being seen in the original series.