Bernard "Barney" Rubble and Elizabeth "Betty" Jean Rubble are a married couple who live next door to Dexter. They appeared in separate cameos in Season Two, Episode 44: Dad is Disturbed; voiced by Jeff Bennett and Kath Soucie, respectively. Their appearance and names are a reference to The Flintstones characters of the same name.
- Unlike their appearance in the Flintstones, Barney and Betty wear modern clothing and wear shoes instead of bare-feet. However, their clothing is heavily inspired by their Stone Age Ones, with Betty wearing a blue dress and bow and Barney wearing a brown shirt.